Recombinant Human Anti-TGF-beta Monoclonal Antibody

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A recombinant human IgG4 monoclonal antibody directed against transforming growth factor-beta (TGFb) with potential antineoplastic activity. Recombinant human anti-TGF-beta monoclonal antibody specifically targets and binds to all 3 isoforms of TGFb, thereby neutralizing TGFb isoforms 1, 2 and 3. This prevents activation of TGFb-mediated signaling pathways. TGFb, a pleiotropic cytokine, is often overexpressed in a number of cancer cell types and is involved in cancer cell proliferation, differentiation, migration, invasion and angiogenesis.

**Synonyms:** - GC1008 - GC1008 - Recombinant Human Anti-Transforming Growth Factor-beta Monoclonal Antibody