Iodine I 131 Iopofosine

**Semantic type:** Amino Acid, Peptide, or Protein|Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radioconjugate composed of iopofosine, a phospholipid ether analog, labeled with the radioactive isotope iodine I 131, with potential antineoplastic activity. Upon administration, iodine I 131 iopofosine selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD) in tumor cells compared to normal cells, thereby delivering cytotoxic radiation specifically to tumor cells. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids.

**Synonyms:** - 131I-CLR1404 - 131I-NM-404 - 131I-NM404 - CLR 131 - CLR 1404 I-131 - CLR-131 - CLR-1404 I-131 - CLR131 - I-131 PLE Analogue CLR1404 - I-131-CLR1404 - I-131-CLR1404 - IOPOFOSINE I-131 - Iopofosine I 131 - NM-404 I-131 - PDC CLR 131 - Phospholipid Ether-drug Conjugate CLR 131 - [(131)I]NM404 - [131I]-CLR1404