Sulindac

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)

**Synonyms:** - (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid - Aflodac - Algocetil - Apo-Sulin - Arthrocine - Artribid - Citireuma - Clinoril - Clisundac - Imbaral - MK-231 - Novo-Sundac - Reumofil - Reumyl - SULINDAC - Sudac - Sulindac Sulfoxide - Sulinol - Sulreuma - cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid - sulindac