Multi-epitope TARP-pulsed Autologous Dendritic Cell Vaccine

**Semantic type:** Cell|Immunologic Factor|Pharmacologic Substance

**Definition:** A cell-based cancer vaccine comprised of autologous dendritic cells pulsed with multiple antigenic peptides derived from T-cell receptor gamma-chain alternate reading frame protein (TARP), with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, multi-epitope (ME) TARP-pulsed autologous dendritic cell vaccine may stimulate anti-tumor cytotoxic T-lymphocyte (CTL) and antibody responses against TARP-expressing cancer cells, resulting in tumor cell lysis. The highly immunogenic nuclear protein TARP is expressed in a variety of cancer cell types.

**Synonyms:** - Autologous TARP Peptide-pulsed Dendritic Cell Vaccine - ME T-cell Receptor Gamma Alternate Reading Frame Protein Peptide-pulsed Autologous DC Vaccine - Multi-epitope TARP Peptide-pulsed Autologous Dendritic Cell Vaccine - Multi-epitope TARP-pulsed Autologous DC Vaccine