Macro Broth Dilution Method

**Semantic type:** Laboratory Procedure

**Definition:** A method to determine the minimum inhibitory concentration (MIC) of antibiotics in which growth media is pipetted into a test tube. Each tube contains a known concentration of drug and is inoculated with a known quantity of bacteria. The tubes are incubated for a specified period of time and each is assessed for bacterial cell growth. The drug concentration in the first tube showing no growth is known as the MIC for that antibiotic.

**Synonyms:** - MACRO BROTH DILUTION