Aggressive NK-Cell Leukemia

**Semantic type:** Neoplastic Process

**Definition:** A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.

**Synonyms:** - Aggressive NK-Cell Leukemia/Lymphoma - Aggressive NK-cell leukaemia - NK Cell Leukemia - NK-Cell Leukemia - Natural Killer Cell Leukemia