Tetradecanoylphorbol Acetate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)

**Synonyms:** - 12-O-tetradecanoylphorbol-13-acetate - 12-O-tetradecanoylphorbol-13-acetate - Lonomycin - PHORBOL 12-MYRISTATE 13-ACETATE DIESTER - PMA - Phorbol Myristate Acetate - TPA - TPA (Phorbol Ester) - tetradecanoylphorbol acetate