Brotizolam

**Semantic type:** Pharmacologic Substance

**Definition:** A triazolo-benzodiazepine derivative with sedative, hypnotic, anxiolytic and anticonvulsant activities. Brotizolam binds to the benzodiazepine binding site on the gamma aminobutyric acid (GABA)-A receptor in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization and increases the inhibitory effect of GABA on the CNS.

**Synonyms:** - 2-Bromo-4-(O-Chlorophenyl)-9-Methyl-6H-Thieno(3,2-F)-S-Triazolo(4,3-A)(1,4)Diazepine - 6H-Thieno(3,2-F)(1,2,4)Triazolo(4,3-A)(1,4)Diazepine,2-Bromo-4-(2-Chlorophenyl)-9-Methyl- - BROTIZOLAM - WE-941