Deflazacort

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic glucocorticoid prodrug, with anti-inflammatory and immunomodulating properties. Upon administration, the active metabolite of deflazacort, 21-desacetyl deflazacort, binds to and activates tissue glucocorticoid receptors. This results in the inhibition of specific leukocyte functions and the inhibition of proinflammatory cytokine production.

**Synonyms:** - 11Beta,21-Dihydroxy-2'-Methyl-5'Beta-H-Pregna-1,4-Dieno(17,16-D)Oxazole-3,20-Dione 21-Acetate - 5'H-Pregna-1,4-Dieno(17,16-d)Oxazole-3,20-Dione, 21-(Acetyloxy)-11-Hydroxy-2'-Methyl-, (11Beta,16Beta)- - DEFLAZACORT - Emflaza - MDL 458