Aprosulate

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic sulfated bis(lactobionic acid amide) derivative and heparin analogue with anticoagulant activity. Aprosulate is made up of two fully sulfated lactobionic acid moieties with a diamine spacer via two amide bonds. This agent inhibits thrombin by antagonizing heparin cofactor II (HCII) and thus prevents thrombin-induced platelet aggregation. It prolongs clotting time.

**Synonyms:** - APROSULATE - N,N'-Trimethylenebis(Actobionamide) Hexadecakis Sulfate (Ester)