Thioguanine

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)

**Synonyms:** - 2-Amino 6MP - 2-Amino 6MP - 2-Amino-1,7-dihydro-6H-purine-6-thione - 2-Amino-1,7-dihydro-6H-purine-6-thione - 2-Amino-6-mercaptopurine - 2-Amino-6-mercaptopurine - 2-Amino-6-purinethiol - 2-Amino-6-purinethiol - 2-Aminopurin-6-thiol - 2-Aminopurin-6-thiol - 2-Aminopurine-6(1H)-thione - 2-Aminopurine-6(1H)-thione - 2-Aminopurine-6-thiol - 2-Aminopurine-6-thiol - 2-Aminopurine-6-thiol Hemihydrate - 2-Mercapto-6-aminopurine - 6 Mercaptoguanine - 6 Thioguanine - 6-Amino-2-mercaptopurine - 6-Mercapto-2-aminopurine - 6-Mercapto-2-aminopurine - 6-Mercaptoguanine - 6-TG - 6-Thioguanine - 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI) - 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI) - BW 5071 - BW 5071 - Lanvis - Lanvis - THIOGUANINE - Tabloid - Tabloid - Thioguanine Hemihydrate - Thioguanine Hydrate - Tioguanin - Tioguanin - Tioguanine - Tioguanine - WR-1141 - Wellcome U3B - Wellcome U3B - X 27 - X 27 - thioguanine