Edoxudine

**Semantic type:** Pharmacologic Substance

**Definition:** A deoxythymidine analog with activity against herpes simplex virus. Edoxudine is activated by viral thymidine kinase to the 5'-monophosphate which is further phosphorylated by cellular enzymes to the 5'-triphosphate, a competitive inhibitor of the viral-coded DNA polymerase.

**Synonyms:** - 5-Ethyl-2'-Deoxyuridine - EDOXUDINE - EDU - EUDR - ORF 15817 - RWJ 15817 - Uridine, 2'-Deoxy-5-Ethyl-