Thioinosine

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A sulfhydryl analog of inosine and an antimetabolite with potential antineoplastic and immunosuppressive properties. Thioinosine interferes with de novo purine synthesis and perturbs the pool of nucleotides necessary for DNA replication. As a result, this agent inhibits DNA synthesis, blocks cellular proliferation and induces apoptosis.

**Synonyms:** - 6-Mercaptopurine ribonucleoside - 6-Mercaptopurine riboside - 6-mercaptopurine ribonucleoside - 6-mercaptopurine riboside - Mercaptopurine Riboside - THIOINOSINE - inosine, 6-thio - ribosyl-6-mercaptopurine