Fontolizumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal antibody directed against interferon-gamma (IFN-g) with immunomodulatory activity. Fontolizumab binds to and prevents the activity of IFN-g. This leads to a suppression of IFN-g-mediated signaling and thus a suppression of IFN-g immune related responses. IFN-g is a cytokine often overexpressed in various auto-immune diseases.

**Synonyms:** - FONTOLIZUMAB - HUZAF - Immunoglobulin G1, Anti-(Human Interferon Gamma) (Human-Mouse Monoclonal Huzaf Gamma-1-Chain), Disulfide with Human-Mouse Monoclonal Huzaf Light Chain, Dimer