DSP wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human DSP wild-type allele is located in the vicinity of 6p24 and is approximately 45 kb in length. This allele, which encodes desmoplakin protein, plays a role in the regulation of protein-protein interactions in desmosome junctions. Mutations in the gene are associated with several keratodermas and cardiomyopathies.

**Synonyms:** - DPI - DPII - Desmoplakin (DPI, DPII) Gene - Desmoplakin wt Allele - KPPS2 - PPKS2