GPC3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human GPC3 wild-type allele is located in the vicinity of Xq26.1 and is approximately 622 kb in length. This allele, which encodes glypican-3 protein, plays a role in the modulation of cellular interactions with extracellular proteoglycans. Mutation of the gene is associated with Simpson-Golabi-Behmel syndrome and Wilms tumor.

**Synonyms:** - DGSX - GTR2-2 - Glypican 3 wt Allele - Glypican Proteoglycan 3 Gene - MXR7 - OCI-5 - SDYS - SGB - SGBS - SGBS1