Lutetium Lu 177-Edotreotide

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate consisting of the somatostatin analogue edotreotide labeled with lutetium Lu 177 with potential antineoplastic activities. Lutetium Lu 177-edotreotide binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide or TOC) and chelated by the bifunctional, macrocyclic chelating agent dodecanetetraacetic acid (DOTA).

**Synonyms:** - 177Lu-DOTATOC - 177Lu-Edo - 177Lu-Edotreotide - EDOTREOTIDE LUTETIUM LU-177 - Edotreotide Lutetium LU-177 - Lutetium 177Lu-Edotreotide - Lutetium Lu 177 DOTA-Tyr3-octreotide - Lutetium Lu177 Edotreotide - [177LuDOTA]-TOC