ORAI1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ORAI1 wild-type allele is located in the vicinity of 12q24.31 and is approximately 15 kb in length. This allele, which encodes calcium release-activated calcium channel protein 1, is involved in the modulation of both T-cell pathogen response and calcium influx. Mutation of the gene is associated with congenital severe combined immunodeficiency.

**Synonyms:** - CRACM1 - Calcium Release-Activated Calcium Modulator 1 Gene - FLJ14466 - ORAI Calcium Release-Activated Calcium Modulator 1 wt Allele - ORAT1 - TMEM142A - Transmembrane Protein 142A Gene