Recombinant Transforming Growth Factor-Beta

**Semantic type:** Chemical Viewed Functionally

**Definition:** A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta (TGF-beta) with proapoptotic and antineoplastic properties. TGF-beta may suppress tumor cell growth by decreasing the expression of cyclin D1, a cell cycle regulatory protein, and downregulating the expression of the oncogene c-myc. This agent is also involved in T cell-mediated immunosuppression by CD4+CD25+ T cells, which permits cancer cells to evade immune surveillance. (NCI04)

**Synonyms:** - Bone-Derived Transforming Growth Factor - TGF-Beta - Therapeutic Milk Growth Factor - Therapeutic TGF B - Therapeutic TGF-Beta - rTGF-Beta