Tretinoin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties.

**Synonyms:** - (All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid - 2,4,6,8-Nonatetraenoic acid, 3, 7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)- - ATRA - ATRA - Aberel - Aberel - Airol - Airol - Aknoten - Aknoten - All-trans Retinoic Acid - All-trans Vitamin A Acid - All-trans retinoic acid - Avita - Avita - Cordes Vas - Dermairol - Dermairol - Epi-Aberel - Eudyna - Eudyna - Renova - Renova - Retin-A - Retin-A - Retin-A - Retin-A MICRO - Retin-A-Micro - Retinoic Acid - Retisol-A - Ro 5488 - Stieva-A - Stieva-A Forte - TRETINOIN - Trans Retinoic Acid - Trans Vitamin A Acid - Tretinoinum - Vesanoid - Vesanoid - Vitamin A Acid - Vitamin A acid - Vitamin A acid, all-trans- - Vitinoin - all trans-Retinoic acid - all-trans retinoic acid - all-trans-Retinoic acid - all-trans-Vitamin A acid - beta-Retinoic Acid - retinoic acid - trans-Retinoic Acid - trans-Retinoic acid - tretinoin - vitamin A acid