PI3Ka/mTOR Inhibitor PKI-179

**Semantic type:** Pharmacologic Substance

**Definition:** A second generation, small-molecule mimetic of ATP that targets the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. PKI-179 selectively inhibits mTOR and phosphoinositide-3-kinase (PI3K) alpha. By inhibiting the PI3K/mTOR signaling pathway, this agent may inhibit tumor cell proliferation and survival.

**Synonyms:** - PKI-179 - PKI-179