Trimethoprim-Sulfamethoxazole

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as Co-Trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthase.

**Synonyms:** - Bactrim - Bactrim - Bactrim DS - Bactrimel - Centran - Centrin - Co-Trimoxazole - Co-Trimoxazole - Cotrim - Cotrimoxazole - Eslectin - Insozalin - SMZ-TMP - Septra - Sulfamethoprim - Sulfatrim - Sulmeprim - TMP-SMX - Trimedin - Trimethoprim/Sulfamethoxazole - Trimethoprim/Sulfamethoxazole (Bactrim DS) - Trimezole - Uroplus - co-trimoxazole - trimethoprim-sulfamethoxazole