Flutemetamol F 18

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Organic Chemical|Pharmacologic Substance

**Definition:** A radiopharmaceutical containing flutemetamol, a thioflavin derivative of Pittsburgh compound B (PiB) labeled with the radioisotope fluorine F18 that can be used to detect beta-amyloid deposition upon positron emission tomography (PET). After intravenous administration of flutemetamol F 18, the flutemetamol moiety selectively accumulates in and binds to cerebral fibrillar amyloid-beta in the brain. The fluorine F18 radioisotope moiety is detected using PET, which allows imaging and quantification of amyloid-beta density. Amyloid plaque deposition is linked to cognitive decline, including Alzheimer's disease, and may be linked to chemotherapy-induced cognitive impairment (CICI).

**Synonyms:** - 2-[3-(18F)Fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol - FLUTEMETAMOL F-18 - Fluorine F 18 Flutemetamol - Flutemetamol F-18 - Vizamyl - [18F]FPIB - [18F]Flutemetamol - [18F]GE-067