Reteplase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme|Pharmacologic Substance

**Definition:** A recombinant, non-glycosylated deletion mutein of tissue plasminogen activator (tPA), a serine protease that catalyzes the cleavage of plasminogen to plasmin, with fibrinolytic activity. Upon administration, reteplase converts plasminogen to plasmin, thereby increasing plasmin enzymatic activity and resulting in degradation of the fibrin matrix of the thrombus and potential dissolution of a thrombus or embolism.

**Synonyms:** - BM-06022 - CUSA 081 - CUSA-081 - CUSA081 - Human T-PA (Amino Acids 1-3 and 176-527) - RETEPLASE - Retavase