Canosimibe

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A derivative of the cholesterol absorption inhibitor ezetimibe designed to be non-soluble and target the luminal surface of the GI tract. In Phase II trials canosimibe reduced LDL cholesterol levels, but it did not demonstrate the desired efficacy in a Phase III study, and was discontinued.

**Synonyms:** - CANOSIMIBE