LIG1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LIG1 wild-type allele is located within 19q13.2-q13.3 and is approximately 55 kb in length. This allele, which encodes DNA ligase 1 protein, is involved in DNA replication and repair. Mutations of the gene that decrease the enzymatic activity of the protein product are associated with immunodeficiency and increased sensitivity to DNA-damaging agents.

**Synonyms:** - Ligase I, DNA, ATP-Dependent wt Allele - MGC117397 - MGC130025 - Polydeoxyribonucleotide Synthase ATP 1 Gene