Mitoguazone Dihydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt of a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation.

**Synonyms:** - 1,1'-((Methylethanediylidene)Dinitrilo)Diguanidine Dihydrochloride - 2,2'-(1-Methyl-1,2-Ethanediylidene)Bis(Hydrazinecarboximidamide) Dihydrochloride - MGBG 2HCl - MITOGUAZONE DIHYDROCHLORIDE - Methylglyoxal Bis(amidinohydrazone) Dihydrochloride - Pyruvaldehyde Bis(amidinohydrazone) Hydrochloride - mitoguazone dihydrochloride