Anal Squamous Cell Carcinoma

**Semantic type:** Neoplastic Process

**Definition:** A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC.

**Synonyms:** - Anal Squamous Cell Cancer - Epidermoid Anal Carcinoma - Epidermoid Carcinoma of Anus - Epidermoid Carcinoma of the Anus - Squamous Cell Anal Carcinoma - Squamous Cell Carcinoma of Anus - Squamous Cell Carcinoma of the Anus - Squamous cell carcinoma - anus - Squamous cell carcinoma of the anus