mTOR Signaling Pathway PID

**Semantic type:** Functional Concept

**Definition:** A complex set of signal transduction pathways described by the NCI Pathway Interaction Database (PID), where each pathway is dependent on the activity of serine/threonine-protein kinase mTOR. This kinase is part of 2 structurally and functionally distinct signaling complexes, mTOR complex 1 and 2 (mTORC1 and mTORC2, respectively), which together regulate the expression of genes that respond to cellular exposure to hormones, growth factors, nutrients and stress signals.

**Synonyms:** - mTOR Signaling Pathway - mTOR signaling pathway