Oncolytic Newcastle Disease Virus MTH-68H

**Semantic type:** Pharmacologic Substance|Virus

**Definition:** An oncolytic viral agent containing the oncolytic, live-attenuated strain of the paramyxovirus Newcastle disease virus (NDV), with potential antineoplastic activity. Upon administration, NDV MTH-68H specifically infects and replicates in cancer cells. This may result in a direct cytotoxic effect involving the lysis of tumor cells via apoptotic mechanisms and may eventually lead to an inhibition of cancer cell proliferation.

**Synonyms:** - MTH-68H - Oncolytic NDV MTH-68H