Fluorine F-18 6-Fluorodopamine

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate consisting of 6-fluorodopamine labeled with fluorine F18 (6-[18F]FDA), with potential diagnostic activity. Upon administration, 6-[18F]FDA is taken up by presynaptic sympathetic nerve endings via the norepinephrine transporter (NET) uptake-1. Once inside, 6-[18F]FDA is rapidly converted by dopamine-beta-hydroxylase into 6-[18F]fluoronorepinephrine (6-[18F]FNE) and stored into neuronal storage vesicles. Upon positron emission tomographic (PET) scanning of the F18, sympathetic innervated regions can be visualized, such as those in pheochromocytoma.

**Synonyms:** - 1,2-Benzenediol, 4-(2-Aminoethyl)-5-(fluoro-18F)- - 18F-DA - 18F-fluorodopamine - 3,4-Dihydroxy-6-fluorophenethylamine F-18 - 6-(18F)-Fluorodopamine - 6-FLUORODOPAMINE F-18 - 6-Fluorodopamine F-18 - Fluorine F-18 6-Fluorodopamine - [18F]-6F-DA - [18F]-6F-dopamine