RUNX2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RUNX2 wild-type allele is located in the vicinity of 6p21 and is approximately 223 kb in length. This allele, which encodes runt-related transcription factor 2 protein, is involved in osteoblastic differentiation, skeletal morphogenesis and hematopoietic stem cell differentiation. Mutation of the gene is associated with cleidocranial dysplasia.

**Synonyms:** - AML3 - CBFA1 - CCD - CCD1 - MGC120022 - MGC120023 - OSF-2 - OSF2 - PEA2aA - PEBP2A1 - PEBP2A2 - PEBP2aA - PEBP2aA1 - Runt-Related Transcription Factor 2 wt Allele