CYLD wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYLD wild-type allele is located in the vicinity of 16q12.1 and is approximately 60 kb in length. This allele, which encodes ubiquitin carboxyl-terminal hydrolase CYLD protein, plays a role in the regulation of both protein ubiquitination and the cell cycle. Mutation of the gene is associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome and may be associated with many types of cancer.

**Synonyms:** - BRSS - CDMT - CYLD Lysine 63 Deubiquitinase wt Allele - CYLD1 - CYLDI - Cylindromatosis (Turban Tumor Syndrome) Gene - EAC - FLJ20180 - FLJ31664 - FLJ78684 - FTDALS8 - HSPC057 - KIAA0849 - MFT - MFT1 - SBS - TEM - USPL2 - Ubiquitin Specific Peptidase Like 2 Gene