TCL1A wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TCL1A wild-type allele is located in the vicinity of 14q32.1 and is approximately 4 kb in length. This allele, which encodes T-cell leukemia/lymphoma protein 1A, plays a role in the modulation of signal transduction. Chromosomal aberrations involving the gene are associated with chronic T-cell leukemia, including translocation t(14;14)(q11;q32) which involves the T-cell receptor beta locus; and translocation t(7;14)(q35;q32) and inversion inv(14)(q11;q32) which both involve the T-cell receptor alpha/delta loci.

**Synonyms:** - Oncogene TCL1 - T-Cell Leukemia/Lymphoma 1A Gene - TCL1 - TCL1 Family AKT Coactivator A wt Allele