Strontium Ranelate

**Semantic type:** Pharmacologic Substance

**Definition:** The ranelate salt form of strontium, that was used for the treatment of osteoporosis. Upon oral administration, strontium binds to and activates the calcium-sensing receptor (CaSR), which promotes osteoblastic differentiation and decreases osteoclast differentiation. This increases bone formation and decreases bone resorption, and rebalances bone turnover, resulting in bone formation.

**Synonyms:** - 5-(Bis(Carboxymethyl)Amino)-2-Carboxy-4-Cyano-3-Thiopheneacetic Acid Strontium Salt (1:2) - Protelos - STRONTIUM RANELATE - strontium ranelate