Vindesine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04)

**Synonyms:** - 3-(Aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine - Compound 112531 - DAVA - DAVA - DVA - Deacetyl Vinblastine Carboxamide - Deacetylvinblastine Carboxamide - Desacetylvinblastine Amide - Lilly CT-3231 - VDS - VINDESINE - VINDESINE - vindesine