Bisphosphonate-Associated Osteonecrosis

**Semantic type:** Disease or Syndrome

**Definition:** Necrosis of the mandible or maxilla in patients receiving intravenous or oral bisphosphonate therapy. It usually manifests with slow healing or failure to heal of a jaw bone following oral surgery. In a minority of cases, the necrosis appears spontaneously. Signs and symptoms include pain, swelling and infection of the affected area.

**Synonyms:** - BON - bisphosphonate-associated osteonecrosis