Warfarin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.

**Synonyms:** - 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone - 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin - 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin - 3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin - 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin - 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one - Co-Rax - Compound 42 - Compound 42 - Rodex - WARF Compound 42 - WARF compound 42 - WARFARIN - warfarin