TRIM21 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TRIM21 wild-type allele is located in the vicinity of 11p15.5 and is approximately 9 kb in length. This allele, which encodes E3 ubiquitin-protein ligase TRIM21 protein, plays a role in the regulation of both cell cycle progression and ubiquitinylation of proteins. Polymorphism of the gene is associated with systemic lupus erythematosus.

**Synonyms:** - Autoantigen Ro/SSA, 52-kDa Gene - RNF81 - RO52 - SSA - SSA1 - Sicca Syndrome Antigen A Gene - Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro) Gene - Sjögren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro) Gene - Tripartite Motif-Containing 21 wt Allele