ICOS wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ICOS wild-type allele is located in the vicinity of 2q33 and is approximately 25 kb in length. This allele, which encodes inducible T-cell costimulator protein, plays a role in the modulation of T-cell mediated immunity. Mutation of the gene is associated with common variable immunodeficiency type 1.

**Synonyms:** - AILIM - Activation-Inducible Lymphocyte Immunomediatory Molecule Gene - CD278 - Inducible Costimulatory Gene - Inducible T-Cell Co-Stimulator wt Allele - MGC39850