Stage 4S Neuroblastoma

**Semantic type:** Neoplastic Process

**Definition:** Localized primary tumor, as defined for stage 1, 2A, or 2B, with dissemination limited to skin, liver, and/or bone marrow (limited to infants younger than 1 year). Marrow involvement should be minimal (i.e., <10% of total nucleated cells identified as malignant by bone biopsy or by bone marrow aspirate). More extensive bone marrow involvement would be considered stage 4 disease. The results of the MIBG scan, if performed, should be negative for disease in the bone marrow. (cancer.gov)

**Synonyms:** - Neuroblastoma Stage IVS - Pepper's Syndrome - Stage IVS Neuroblastoma