PSEN2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PSEN2 wild-type allele is located within 1q31-q42 and is approximately 26 kb in length. This allele, which encodes presenilin-2 protein, plays a role in the modulation of proteolysis. Mutation of the gene is associated with Alzheimer disease.

**Synonyms:** - AD3L - AD4 - Alzheimer's Disease 3-Like Gene - PS2 - Presenilin 2 (Alzheimer Disease 4) wt Allele - STM2