Fostamatinib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A small molecule Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.

**Synonyms:** - (6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-yl)Amino)-2,2-Dimethyl-3-Oxo-2,3-Dihydro-4H-Pyrido(3,2-B)(1,4)Oxazin-4-Yl)Methyl Dihydrogen Phosphate - 2H-Pyrido(3,2-B)-1,4-Oxazin-3(4H)-One, 6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)-4-Pyrimidinyl)Amino)-2,2-Dimethyl-4-((Phosphonooxy)Methyl)- - FOSTAMATINIB - R 788 Free Acid - R 935788 Free Acid - R-788 Free Acid - R-935788 Free Acid - R788 Free Acid