Core Histone Macro-H2A

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A histone protein that is comprised of a histone H2A domain, which allows interaction with the nucleosome, and a macro domain, which may bind to ADP-ribose. This protein can substitute for histone H2A in the nucleosomal complex and plays a role in transcriptional repression and X chromosome inactivation.

**Synonyms:** - Histone MacroH2A - MacroH2A - mH2A - mH2A