LRP5 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LRP5 wild-type allele is located in the vicinity of 11q13.4 and is approximately 137 kb in length. This allele, which encodes low-density lipoprotein receptor-related protein 5, plays a role in the modulation of both receptor mediated endocytosis and Wnt signaling pathways. Mutation of the gene is associated with vitreoretinopathy exudative type 4 and several bone disorders.

**Synonyms:** - BMND1 - EVR1 - EVR4 - Exudative Vitreoretinopathy 1 Gene - Exudative Vitreoretinopathy 4 Gene - HBM - LR3 - LRP7 - Low Density Lipoprotein Receptor-Related Protein 5 wt Allele - Low Density Lipoprotein Receptor-Related Protein 7 Gene - OPPG - OPS - OPTA1 - Osteoporosis Pseudoglioma Syndrome Gene - VBCH2