BUB1B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human BUB1B wild-type allele is located in the vicinity of 15q15 and is approximately 60 kb in length. This allele, which encodes mitotic checkpoint serine/threonine-protein kinase BUB1 beta protein, plays a role in the modulation of protein phosphorylation and mitotic spindle checkpoint control. Mutation of the gene is associated with colorectal cancer, mosaic variegated aneuploidy syndrome and premature chromatid separation trait and may be involved in other carcinomas.

**Synonyms:** - BUB1 Mitotic Checkpoint Serine/Threonine Kinase B wt Allele - BUB1, Mitotic Checkpoint Serine/Threonine Kinase B Gene - BUB1, S. cerevisiae, Homolog of, Beta Gene - BUB1beta - BUBR1 - Bub1A - Budding Uninhibited By Benzimidazoles 1 (Yeast Homolog), Beta Gene - Budding Uninhibited By Benzimidazoles 1 Homolog Beta (Yeast) Gene - Budding Uninhibited By Benzimidazoles 1 Homolog Beta Gene - Budding Uninhibited by Benzimidazoles 1, S. cerevisiae, Homolog of, Beta Gene - MAD3L - MVA1 - Mitotic Checkpoint Gene BUB1B - SSK1 - hBUBR1