Esophageal Neuroendocrine Carcinoma

**Semantic type:** Neoplastic Process

**Definition:** An aggressive high-grade carcinoma with neuroendocrine differentiation that arises from the esophagus. It is composed of malignant small or large cells. The mitotic count is more than 20 per 2 mm2 and/or the Ki-67 index is more than 20%.

**Synonyms:** - Esophageal High Grade Neuroendocrine Carcinoma - Esophageal NEC - Esophageal Neuroendocrine Cancer - Esophageal Poorly Differentiated Endocrine Carcinoma - Esophageal Small and Large Cell Endocrine Carcinoma