MTF-1 Inhibitor APTO-253 HCl

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt of a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor APTO-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.

**Synonyms:** - 2-(6-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline Hydrochloride - APTO-253 HCl - APTO-253 HYDROCHLORIDE - LOR-253 HCl - LT-253 HCl