Mavrilimumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A human IgG4 monoclonal antibody targeting the alpha chain of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSF-Ra), with potential immunomodulating activity. Mavrilimumab binds to GM-CSF-Ra and inhibits the GM-CSF-mediated pathway. This may inhibit inflammation. GM-CSF and its receptor are upregulated in a number of autoimmune diseases and play a key role in the activation, differentiation and function of both granulocytes and monocytes.

**Synonyms:** - CAM-3001 - Immunoglobulin G4, Anti-(Human Granulocyte-Macrophage Colony-Stimulating-Factor Receptor alpha-Chain) (Human Monoclonal CAM-3001 Heavy Chain), Disulfide with Human Monoclonal CAM-3001 lambda-Chain, Dimer - MAVRILIMUMAB