NEDD8 Activating Enzyme

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** NEDD8 activating enzyme is comprised of NEDD8-activating enzyme E1 regulatory subunit and NEDD8-activating enzyme E1 catalytic subunit. This protein complex modifies the C-terminus of NEDD8 to regulate protein neddylation, ubiquitination and catabolism.

**Synonyms:** - NAE - NEDD8 Activating E1 Enzyme - NEDD8-Activating Enzyme - UBA3-NAE1 E1 Enzyme